Morphological Definition of Actin Architecture at the T Cell Immunological Synapse

T lymphocytes (T cells) are the major mediators of adaptive immune response. They detect pathogens primarily via interaction their cell receptor (TCR) with cognate pathogen-derived peptide displayed in context MHC on infected cell. A critical step activation is formation immunological synapse, a specialized cell–cell conjugate interface between and cell, where massive TCR-induced actin remodeling polymerization take place. Dynamic at synapse essential for subsequently,